Cannabis edibles and oral dosage forms suffer from low bioavailability of cannabinoids. Cannabinoids are the active ingredients found in the plant and it's extracts. When taken orally only 4%-12% of the total cannabinoids consumed reach the bloodstream [1]. In comparison smoking cannabis can reach a bioavailability above 50% within minutes of inhalation [2-5]. Furthermore, the poor bioavailability of cannabinoids results in delayed onset; effects are typically felt between 60 to 120 minutes before [6].
